Horseradish was widely used as a medicine during the Middle Ages. It was traditionally used for its heating, congestion clearing (especially sinus congestion), and antiseptic action; but also to help reduce fluid retention and to improve sluggish digestion.

Horseradish was also traditionally employed as a remedy for worms in children: 'Of all things given to children for worms, horseradish is not the least, for it soon killeth and expelleth them.'

Today, Horseradish is used to treat various health problems, including urinary tract infections, bronchitis, and sinus congestion. It is said to be very effective in getting rid of the persistent cough that can follow influenza. Compounds found in horseradish have also been found to kill some bacterial strains.

Horseradish contains several nutrients including minerals, Vitamin C, and Sulfur. This makes it an excellent skin tonic and cleanser.